Step 4: Calculate partition coefficients (log P)

Select 'Solvent Log Partition Coefficients' from the 'Properties' Menu
Select 'benzene' for the first component in Solvent 1
Select 'water' for the first component in Solvent 2
Click 'Yes' in the 'Use input volume quotient' field
Enter '4.93' in the 'Input volume solvent/solvent 2' field
Select 'Run' command from the 'File' menu
Click 'Yes' when asked to 'Save changes (required to run)?'

In case of partly miscible liquids, like, for example, the octanol-rich phase of octanol and water, both components have nonzero mole fractions.

Here an input value is used for the volume quotient of the two solvents. If one does not include such value, the program will use the COSMO volumes to calculate the volume quotient. The COSMO volumes can be found in the 'Compound' window.

The result of the calculation is given in the form of a table.