Strong NMR enhancement: PHIP-X

NMR signals are often too weak for many chemical and biomedical applications such as reaction monitoring or the real time investigation of metabolism in-vivo. A new method has been developed to enhance NMR signals: parahydrogen-induced polarization relayed via proton exchange (PHIP-X). The novel methodology achieves boosts of more than 50,000.

PHIP-X combines strong polarizations obtained from PHIP with the broad applicability of polarization transfer via proton exchange as demonstrated in SABRE-Relay (Signal Amplification by Reversible Exchange). PHIP-X can enhance both 1H as well as 13C signals. The technique was demonstrated to strongly boost the NMR signals of different alcohols, water, lactic acid, pyruvic acid, and glucose.

With such strong and versatile NMR enhancements, PHIP-X provides a new foundation for many potential applications of NMR in chemistry and biomedicine.


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K. Them et al., Parahydrogen-Induced Polarization Relayed via Proton Exchange, J. Am. Chem. Soc. 143, 13694 (2021)

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